Ọrịa obi, nke bụ isi ihe na-ebute ọnwụ nke ọrịa ndị na-adịghị agbasa, bụ ọrịa nke metụtara ịka nká.Site na mmụba nke afọ, obi, dị ka akụkụ ahụ na-agbapụta ọbara, ga-aka nká, ikike izu ike na nkwekọrịta ga-adalata, ọ ga-eji nwayọọ nwayọọ enwekwa ike ịgbanye ọbara n'ahụ dum, nke ga-emecha mee ka obi ghara ịda mbà. ndị ọrịa ma na-emetụta ndụ ahụike ndị mmadụ nke ukwuu.
Ihe e ji mara ịka nká nke obi site na mbelata nke nkwekọrịta obi (ọrụ obi), nke ga-esonyere mbelata nke ụbara protein na mgbanwe mgbanwe mgbanwe protein gachara.
SS-31 peptide bụ cardiolipin peroxidase inhibitor na peptide mitochondrial ezubere iche.Ọ nwere ike melite ọrụ nke ventricle ekpe na mitochondria.SS-31 peptide nwere ike ibelata nrụrụ mitochondrial na mmebi oxidative na sel trabecular meshwork mmadụ.Ọ nwere ike igbochi sel iHTM na GTM(3) site na nrụgide oxidative nke H2O2 kpatara.
SS-31 bụ mitochondrial ezubere iche maka mgbochi ịka nká, bụ nke egosipụtara na ọ dị irè n'iweghachi ọrụ obi nke ụmụ oke merela agadi.Ọ bụ tetrapeptide sịntetik jikọtara ya na akpụkpọ ahụ dị n'ime mitochondrial, nke nwere ike melite ọrụ mitochondrial, belata mmepụta nke ụdị oxygen na-arụ ọrụ ROS, na-ebelata ọkwa nke ihe ndị na-emerụ emerụ ma na-ebuli ọrụ diastolic nke obi.
Nke mbụ, iji ụmụ oke na-eto eto tụnyere ụmụ oke ochie, ndị ọkà mmụta sayensị chọpụtara na ụbara protein mitochondrial na-emetụta nke ukwuu site na ịka nká, gụnyere ụzọ ntụgharị akara mitochondrial, protein ndị metụtara ụzọ phosphorylation oxidative nke na-emepụta ume, na protein ndị metụtara SIRT n'ụzọ ntụgharị mgbaàmà metụtara ike. Metabolism na mitochondria.Na mgbakwunye, protein ndị dị mkpa troponin na tropomyosin, bụ ndị na-egbochi myocardial myocardial ozugbo, na-emetụtakwa ịka nká.Ndị a nwere njikọ chiri anya na ọrụ obi.Nke abuo, mgbe ị na-atụle mmetụta nke ọgwụgwọ SS-31, ndị nchọpụta chọpụtara na ụbara protein nke ụmụ oke ochie a na-emeso adịghị ka nke na-eto eto, ma ha niile gosipụtara mgbake nke ụzọ inactivation na ịka nká, dị ka ụbara protein nke tricarboxylic acid okirikiri, bụ isi ụzọ nke mmepụta ume n'ime ahụ, nke gbakere n'ezie ruo n'ókè dị ukwuu, na-eme ka ochie ụmụ oke na-eto eto.Nke a pụtara na SS-31 dị irè karịsịa maka mgbanwe nke ike metabolism nke obi ịka nká kpatara.Nchọgharị nke ịba ụba protein bịara na njedebe, mgbe ahụ ndị nchọpụta tụgharịrị uche ha na mgbanwe mgbanwe mgbanwe protin n'oge usoro ịka nká, ma họrọ kpọmkwem mgbanwe mgbanwe mgbanwe na protein, bụ nke kachasị emetụta obi. -acetylation mgbanwe.Enwere ike inwe mgbanwe abụọ na mgbanwe acetylation.Nke mbụ, n'ihi na acetylation nke protein mitochondrial ga-abawanye na afọ, na-ebute nkwụsị nke mitochondrial, na ọdịnaya mitochondrial nke obi dị oke elu, ya mere obi dum nwere ike inwe nnukwu nchịkọta acetylation mgbe ọrụ obi na-ebelata;Nke abụọ, a ga-enwe nkwụsị nke acetylation nkịtị nke ihe fọdụrụnụ na usoro ịka nká, nke ga-eduga na ọdịda nke ịrụ ọrụ nkịtị.Ndị nchọpụta emewo ka peptides acetylated dị n'ime obi dịkwuo mma (nke enwere ike ịghọta dị ka obere nkeji eji emepụta protein).A ka nwere ọdịiche dị na ọkwa acetylation nke protein obi n'etiti otu ndị na-eto eto na ndị agadi, ma ọ bụghị ihe doro anya dị ka ụbara protein.Mgbe ahụ, ha nyochakwara n'ihu nke protein mgbanwe a na ọnọdụ acetylation nwere ike bụrụ kpọmkwem.N'ikpeazụ, ndị nchọpụta ahụ jikọtara ọzọ ikike systolic na diastolic nke obi wee chọta saịtị 14 acetylation metụtara ikike diastolic nke obi, na ha niile jikọtara ya na-adịghị mma.N'otu oge ahụ, a chọtakwara saịtị abụọ metụtara mgbakwụnye obi.Nke a pụtara na mgbanwe nke nkwekọrịta n'oge ịka nká nwere ike ịhazi site na acetylation steeti protein obi.
Anyị bụ ndị na-emepụta polypeptide na China, nwere ahụmahụ tozuru okè na mmepụta polypeptide ọtụtụ afọ.Hangzhou Taijia Biotech Co., Ltd bụ ọkachamara polypeptide akụrụngwa emeputa, nke nwere ike inye iri puku kwuru iri puku polypeptide akụrụngwa na nwekwara ike ahaziri dị ka mkpa.Ogo nke ngwaahịa polypeptide dị mma, ịdị ọcha nwere ike iru 98%, nke ndị ọrụ ghọtara n'ụwa niile. Nnọọ ịkpọtụrụ anyị.
