Peptide bụ ngwakọta organic, nke akpọpụtara na amino acid ma nwee otu carboxyl na amino dị iche iche.Ọ bụ ngwakọta amphoteric.Polypeptide bụ ngwakọta nke amino acids jikọtara ọnụ site na njikọ peptide.Ọ bụ ngwaahịa etiti nke protein hydrolysis.A na-etolite ya site na akpịrị ịkpọ nkụ na condensation nke 10 ~ 100 amino acid molecules, na ịdị arọ ya bụ ihe na-erughị 10000Da.Ọ nwere ike banye n'ime akpụkpọ ahụ nke nwere ike ime nke ọma na trichloroacetic acid na ammonium sulfate anaghị ebute ya, gụnyere peptides bioactive na peptides synthetic artificial.
Ọgwụ polypeptide na-ezo aka na polypeptides nwere mmetụta ọgwụgwọ pụrụ iche site na njikọ kemịkalụ, recombination gene na mmịpụta anụmanụ na osisi, nke a na-ekewa n'ime polypeptides endogenous (dị ka enkephalin na thymosin) na polypeptides ndị ọzọ na-apụ apụ (dị ka venom agwọ na sialic acid).Ọnụ ọgụgụ molekụla dị arọ nke ọgwụ polypeptide dị n'etiti ọgwụ protein na ọgwụ micromolecule, nke nwere uru nke ọgwụ micromolecule na ọgwụ protein.E jiri ya tụnyere ọgwụ micromolecule, ọgwụ polypeptide nwere ọrụ ndụ dị elu yana nkọwa siri ike.E jiri ya tụnyere ọgwụ protein, ọgwụ polypeptide nwere nkwụsi ike ka mma, obere immunogenicity, ịdị ọcha dị elu na ọnụ ala dị ala.
Polypeptide nwere ike na-etinye ya ozugbo ma na-arụsi ọrụ ike site na ahụ, na ntinye ọsọ na-adị ngwa ngwa, na ntinye nke polypeptide na-ebute ụzọ.Na mgbakwunye, peptides nwere ike ọ bụghị naanị na-ebu nri, kamakwa na-ebufe ozi cellular iji nye iwu akwara.Ọgwụ polypeptide nwere njirimara nke ọrụ dị elu, nhọrọ dị elu, toxicity dị ala na mmekọrịta dị elu, mana n'otu oge ahụ, ha na-enwekwa ọghọm nke obere ndụ ọkara ndụ, sel sel na-adịghị mma na otu ụzọ nchịkwa.
N'ihi adịghị ike nke ọgwụ polypeptide, ndị nchọpụta emewo mgbalị na-adịghị agwụ agwụ n'okporo ụzọ na-eme ka peptides dịkwuo mma iji meziwanye bioavailability nke ọgwụ polypeptide.Cyclization nke peptides bụ otu n'ime ụzọ na-ebuli peptides, na mmepe nke cyclic peptides emewo ka chi ọbụbọ na ọgwụ polypeptide.Cyclic peptides bara uru na nkà mmụta ọgwụ n'ihi nkwụsi ike ha na-edozi ahụ nke ọma, nhọrọ na mmekọrịta ha, mwepu sel cell na nnweta ọnụ.Cyclic peptides nwere ihe omume dị ndụ dị ka mgbochi ọrịa kansa, mgbochi ọrịa, mgbochi ero na mgbochi nje, na bụ nnọọ ekwe nkwa ụmụ irighiri ọgwụ.N'afọ ndị na-adịbeghị anya, ọgwụ peptide cyclic adọtala mmasị dị ukwuu, ụlọ ọrụ na-emepụta ọgwụ agbasowokwa usoro nke mmepe ọgwụ ọhụrụ ma wepụta usoro ọgwụ peptide cyclic n'otu n'otu.
Dr. Chen Shiyu si Shanghai Institute of Pharmacology, Chinese Academy of Sciences webatara ọgwụ peptide cyclic nke akwadoro site na 2001 ruo 2021 n'ime ọgwụ peptide cyclic ya kwadoro na ọgwụ abụọ ikpeazụ.N'ime afọ 20 gara aga, e nwere ụdị ọgwụ peptide cyclic 18 dị n'ahịa, n'ime nke ọnụ ọgụgụ peptides cyclic na-arụ ọrụ na mgbidi cell na β-1,3-glucanase lekwasịrị anya bụ nke kachasị ukwuu, nwere ụdị 3 ọ bụla.Ọgwụ peptide cyclic akwadoro na-ekpuchi mgbochi ọrịa, endocrine, sistemu nri nri, metabolism, etuto / mgbochi na sistem ụjọ nke etiti, n'etiti nke ọgwụ mgbochi ọrịa na endocrine cyclic peptide ọgwụ ruru 66.7%.N'ihe gbasara ụdị cyclization, enwere ọtụtụ ọgwụ peptide cyclic nke cyclized site na njikọ disulfide na cyclized site na amide bonds, yana ọgwụ 7 na 6 kwadoro n'otu n'otu.
Oge nzipu: Sep-18-2023